Some security software has virtualization or sandbox features that may cause problems by protecting and restoring files in the Firefox profile folder. It is possible that there is a problem with the file(s) that store the extensions registry. Delete the files extensions.* (e.g. extensions.sqlite, extensions.ini, extensions.cache) and compatibility.ini in the Firefox profile folder to reset the extensions registry. *https://support.mozilla.org/kb/Profiles New files will be created when required. See "Corrupt extension files": *http://kb.mozillazine.org/Unable_to_install_themes_or_extensions *https://support.mozilla.org/kb/Unable+to+install+add-ons If you see disabled, not compatible, extensions in "Tools > Add-ons > Extensions" then click the Tools button at the left side of the Search Bar (or click the "Find Updates" button in older Firefox versions) to check if there is a compatibility update available. If this hasn't helped then also try to delete the addons.sqlite file. If you do not keep changes after a restart then also see: *http://kb.mozillazine.org/Preferences_not_saved